The effect of drugs in established rabbit monoarticular arthritis
Identifieur interne : 003952 ( Main/Exploration ); précédent : 003951; suivant : 003953The effect of drugs in established rabbit monoarticular arthritis
Auteurs : Alan Blackham [Royaume-Uni] ; Henryk Radziwonik [Royaume-Uni]Source :
- Agents and Actions [ 0065-4299 ] ; 1977-10-01.
English descriptors
- Teeft :
- Arthritis, Control animals, Cyclophosphamide, Cyproheptadine hydrochloride, Different parameters, Dosing, Drug activity, Drug administration, Drug treatment, French laboratories, Gold triethyl phosphine, Good correlation, High proportion, High tsfc, Histopathology, Indomethacin, Intradermal injection, Joint challenge, Joint histopathology, Joint macroscopy, Joint swellings, Ketoprofen, Knee joints, Levamisole, Macroscopy, Monoarticular, Monoarticular arthritis, Naproxen, Oral dosing, Overt signs, Oxisuran, Penicillamine, Poor responders, Positive correlation, Prednisolone, Prednisolone sodium phosphate, Rabbit, Rabbit monoarticular arthritis, Rheumatoid, Rheumatoid arthritis, Significant inhibition, Skin thickness, Slow onset, Smith kline, Standard deviation, Sudoxicam, Synovial, Synovial fluid, Synovial fluid cells, Syntex pharmaceuticals, Toxicity, Tsfc, Ward blenkinsop.
Abstract
Abstract: Established antigen-induced arthritis was produced in 264 out of 339 sensitied Old English rabbits 4–6 weeks after a single intra-articular injection of ovalbumin into one knee joint. Positive arthritis was diagnosed when the joint swelling at this time was ≥2 mm. A positive correlation between established joint swelling and delayed hypersensitivity to ovalbumin injected intradermally 24 h prior to joint challenge was demonstrated. Groups of 5–10 arthritic rabbits were dosed orally with increasing or fixed doses of a range of drugs for a period of 3–7 weeks. Drug activity was measured on joint swelling intermittently during the test and on joint macroscopy, cell content of the synovial fluid and joint histopathology at the end of the experiment. Prednisolone sodium phosphate and ketoprofen were the most active compounds tested. Chloroquine diphosphate, cyclophosphamide, indomethacin, naproxen, SKF 36914 and sudoxicam had some activity, while aspirin, levamisole, oxisuran and D(−)penicillamine had little or no activity.
Url:
DOI: 10.1007/BF01966856
Affiliations:
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Laboratories, Fisons Ltd., Loughborough, Leicestershire</wicri:cityArea></affiliation></author><author><name sortKey="Radziwonik, Henryk" sort="Radziwonik, Henryk" uniqKey="Radziwonik H" first="Henryk" last="Radziwonik">Henryk Radziwonik</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Biochemical Pharmacology, R. & D. Laboratories, Fisons Ltd., Loughborough, Leicestershire</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Agents and Actions</title><title level="j" type="abbrev">Agents and Actions</title><idno type="ISSN">0065-4299</idno><idno type="eISSN">1420-908X</idno><imprint><publisher>Birkhäuser-Verlag</publisher><pubPlace>Basel</pubPlace><date type="published" when="1977-10-01">1977-10-01</date><biblScope unit="volume">7</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="473">473</biblScope><biblScope unit="page" to="480">480</biblScope></imprint><idno type="ISSN">0065-4299</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0065-4299</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Arthritis</term><term>Control animals</term><term>Cyclophosphamide</term><term>Cyproheptadine hydrochloride</term><term>Different parameters</term><term>Dosing</term><term>Drug activity</term><term>Drug administration</term><term>Drug treatment</term><term>French laboratories</term><term>Gold triethyl phosphine</term><term>Good correlation</term><term>High proportion</term><term>High tsfc</term><term>Histopathology</term><term>Indomethacin</term><term>Intradermal injection</term><term>Joint challenge</term><term>Joint histopathology</term><term>Joint macroscopy</term><term>Joint swellings</term><term>Ketoprofen</term><term>Knee joints</term><term>Levamisole</term><term>Macroscopy</term><term>Monoarticular</term><term>Monoarticular arthritis</term><term>Naproxen</term><term>Oral dosing</term><term>Overt signs</term><term>Oxisuran</term><term>Penicillamine</term><term>Poor responders</term><term>Positive correlation</term><term>Prednisolone</term><term>Prednisolone sodium phosphate</term><term>Rabbit</term><term>Rabbit monoarticular arthritis</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Significant inhibition</term><term>Skin thickness</term><term>Slow onset</term><term>Smith kline</term><term>Standard deviation</term><term>Sudoxicam</term><term>Synovial</term><term>Synovial fluid</term><term>Synovial fluid cells</term><term>Syntex pharmaceuticals</term><term>Toxicity</term><term>Tsfc</term><term>Ward blenkinsop</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Established antigen-induced arthritis was produced in 264 out of 339 sensitied Old English rabbits 4–6 weeks after a single intra-articular injection of ovalbumin into one knee joint. Positive arthritis was diagnosed when the joint swelling at this time was ≥2 mm. A positive correlation between established joint swelling and delayed hypersensitivity to ovalbumin injected intradermally 24 h prior to joint challenge was demonstrated. Groups of 5–10 arthritic rabbits were dosed orally with increasing or fixed doses of a range of drugs for a period of 3–7 weeks. Drug activity was measured on joint swelling intermittently during the test and on joint macroscopy, cell content of the synovial fluid and joint histopathology at the end of the experiment. Prednisolone sodium phosphate and ketoprofen were the most active compounds tested. Chloroquine diphosphate, cyclophosphamide, indomethacin, naproxen, SKF 36914 and sudoxicam had some activity, while aspirin, levamisole, oxisuran and D(−)penicillamine had little or no activity.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Blackham, Alan" sort="Blackham, Alan" uniqKey="Blackham A" first="Alan" last="Blackham">Alan Blackham</name></region><name sortKey="Radziwonik, Henryk" sort="Radziwonik, Henryk" uniqKey="Radziwonik H" first="Henryk" last="Radziwonik">Henryk Radziwonik</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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